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  • NOTUM Gene - GeneCards
    NOTUM (Notum, Palmitoleoyl-Protein Carboxylesterase) is a Protein Coding gene Diseases associated with NOTUM include Dental Pulp Necrosis and Suppurative Periapical Periodontitis
  • Notum | The WNT Homepage
    Notum (also called Wingful) was originally discovered in screens in fruit flies for genes interacting with the Wnt protein Wingless Loss of Notum in flies leads to wing overgrowth, indicating that Wnt proteins (which drive wing growth and patterning) have become unrestrained
  • Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling
    Notum is emerging as a druggable target to modulate Wnt signaling Our emphasis will be on structural biology, modern hit finding approaches, and medicinal chemistry strategies to deliver fit-for-purpose chemical tools
  • NOTUM-mediated WNT silencing drives extravillous trophoblast cell . . .
    Notum, palmitoleoyl-protein carboxylesterase, a WNT signaling antagonist, is involved in promoting and maintaining EVT cell differentiation This process is essential for the proper development of the placenta and is crucial for a healthy pregnancy
  • Notum Is Required for Neural and Head Induction via Wnt Deacylation . . .
    Notum is a secreted Wnt antagonist that belongs to the α β hydrolase superfamily, but its mechanism of action and roles in vertebrate embryogenesis are not fully understood
  • Notum Inhibitors
    Notum is a negative regulator of Wnt, so inhibitors may benefit diseases with reduced Wnt, such as Alzheimer’s disease and osteoporosis, but exacerbate conditions with high Wnt, such as cancer and fibrosis
  • NOTUM plays a bidirectionally modulatory role in the odontoblastic . . .
    By exploring the regulatory role and mechanism of NOTUM on the odontoblastic differentiation of hSCAPs, we demonstrate NOTUM as a new regulatory target for hSCAPs’ odontoblastic differentiation and provide new insights for the regeneration of the pulp-dentin complex





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