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  • Variant of Uncertain Significance (VUS)
    When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
  • What to do if your genetic test finds a variant of uncertain . . .
    But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
  • Assessing a Variant of Uncertain Significance (VUS)
    Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
  • VUS – The Most Maligned Result in Genetic Testing
    The classification of genetic variants, based on the ACMG guidelines, is usually a five-tiered scheme which describes the quantity and quality of evidence needed to classify the variant as pathogenic, likely pathogenic, a variant of uncertain significance (VUS), likely benign, or benign
  • VUS Variant of Uncertain Significance for cancer patients - MC1185-82
    Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
  • Genetic Test Result: VUS - Variant of Uncertain Significance
    A VUS result could get changed to either benign or pathogenic with new information For some variants, a different test can measure if the gene is working or not
  • Variants of uncertain significance (VUS)
    Variants of uncertain significance (VUS) This communication aid has been produced for clinicians to help support and guide conversations about variant classification and variants of uncertain significance with their patients
  • Variant of uncertain significance (VUS) — Knowledge Hub
    A variant of uncertain significance (VUS) describes a genomic variant about which there is insufficient data to conclude that it is either benign or pathogenic
  • Considerations for Variants of Uncertain Significance (VUS)
    Variants with insufficient or conflicting evidence supporting disease association, which cannot be classified as ‘pathogenic likely pathogenic’ (disease-associated), nor as ‘benign likely benign’ (not disease-associated), are called Variants of Uncertain Significance (VUS)





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