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  • 3D printed porous magnesium metal scaffolds with bioactive coating for . . .
    In orthopedics, the effective treatment of bone defects remains a major challenge Magnesium (Mg) metals, with their excellent biocompatibility and favorable osteoconductivity, osteoinductivity, and osseointegration properties, hold great promise for addressing this issue However, the rapid degradation rate of magnesium restricts its clinical application In this study, a triply periodic
  • Biomimetic calcium carbonate nanoparticles delivered IL-12 mRNA for . . .
    Biomimetic calcium carbonate nanoparticles delivered IL-12 mRNA for targeted glioblastoma sono-immunotherapy by ultrasound-induced necroptosis | Journal of Nanobiotechnology | Full Text
  • Combination therapy with ultrasound and 2D nanomaterials promotes . . .
    Combination therapy with ultrasound and 2D nanomaterials promotes recovery after spinal cord injury via Piezo1 downregulation | Journal of Nanobiotechnology | Full Text
  • A sensitive and rapid electrochemical biosensor for sEV-miRNA detection . . .
    A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly | Journal of Nanobiotechnology | Full Text
  • Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking . . .
    Cyanine dye-containing nanoparticles have widely been used in “all-in-one” NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modulation methods to tune absorption and emission wavelengths The combination of good brightness and excellent tumor-targeting capacity is the key to
  • Celery seed derived reconstituted lipid nanoparticles as an innate . . .
    Background Ischemic stroke (IS) is the leading cause of worldwide death while the discovery and effective delivery of neuroprotective agents for satisfied IS treatment is still challenging Results In this study, we discover that celery seed (CS) derived reconstituted lipid nanoparticles (CS-rLNPs) can effectively penetrate across blood-brain barrier (BBB) with increased distribution to the
  • A metal-organic nanoframework for efficient colorectal cancer . . .
    Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS NPs), capable of efficient cGAS-STING pathway activation and immune checkpoint blockade, by encapsulating the chemotherapeutic mitoxantrone (MTX) and
  • Co-freezing localized CRISPR-Cas12a system enables rapid and sensitive . . .
    Rapid and sensitive nucleic acid detection is vital in disease diagnosis and therapeutic assessment Herein, we propose a co-freezing localized CRISPR-Cas12a (CL-Cas12a) strategy for sensitive nucleic acid detection The CL-Cas12a was obtained through a 15-minute co-freezing process, allowing the Cas12a crRNA complex and hairpin reporter confined on the AuNPs surface with high load efficiency
  • Locally administered liposomal drug depot enhances rheumatoid arthritis . . .
    Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by synovial hyperplasia, where inflammatory macrophages within the joint synovium produce multiple inflammatory cytokines, leading to cartilage damage The development of therapeutic strategies that combine anti-inflammatory effects and cartilage repair mechanisms holds great promise for effective RA treatment To





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